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Julie De Backer Selected Research

Marfan Syndrome (Marfan's Syndrome)

11/2021Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO.
1/2021An Overview of Investigational and Experimental Drug Treatment Strategies for Marfan Syndrome.
1/2021Cardiomyopathy in Genetic Aortic Diseases.
10/2020Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome.
9/2020Spontaneous Right Ventricular Pseudoaneurysms and Increased Arrhythmogenicity in a Mouse Model of Marfan Syndrome.
12/2019Angiotensin-II receptor blockade in Marfan syndrome.
11/2019Case-matched Comparison of Cardiovascular Outcome in Loeys-Dietz Syndrome versus Marfan Syndrome.
1/2018Influence of Aortic Stiffness on Aortic-Root Growth Rate and Outcome in Patients With the Marfan Syndrome.
12/2017Efficacy of losartan as add-on therapy to prevent aortic growth and ventricular dysfunction in patients with Marfan syndrome: a randomized, double-blind clinical trial.
2/2017Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.
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Julie De Backer Research Topics

Disease

17Marfan Syndrome (Marfan's Syndrome)
11/2021 - 08/2009
8Aneurysm (Aneurysms)
01/2021 - 03/2005
6Cardiomyopathies (Cardiomyopathy)
09/2020 - 06/2009
5Aortic Diseases
06/2022 - 12/2016
5Aortic Dissection
01/2021 - 05/2013
4Thoracic Aortic Aneurysm
01/2021 - 05/2013
4Heart Failure
12/2019 - 09/2013
3Congenital Heart Defects (Congenital Heart Defect)
11/2021 - 03/2005
3Cardiac Arrhythmias (Arrythmia)
01/2021 - 10/2011
3Cicatrix (Scar)
12/2019 - 10/2012
3Loeys-Dietz Syndrome
11/2019 - 04/2006
3Rupture
01/2018 - 04/2007
2Cardiac Sudden Death (Sudden Cardiac Arrest)
09/2020 - 01/2010
2Aortic Aneurysm (Aneurysm, Aortic)
01/2020 - 04/2006
2Neoplasms (Cancer)
01/2020 - 12/2008
2Fatigue
12/2019 - 10/2010
2Type IV Ehlers-Danlos Syndrome
12/2017 - 10/2010
2Left Ventricular Dysfunction
12/2014 - 01/2010
2Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos)
10/2012 - 04/2007
2Breast Neoplasms (Breast Cancer)
12/2008 - 08/2008
1Thrombosis (Thrombus)
01/2021
1Chronic Disease (Chronic Diseases)
08/2020
1Atherosclerosis
01/2020
1Central Sleep Apnea (Central Sleep Apnea Syndrome)
12/2019
1Spontaneous Coronary Artery Dissection
12/2019
1Bicuspid Aortic Valve Disease
12/2019
1Biliary Tract Diseases
12/2019
1Coronary Artery Disease (Coronary Atherosclerosis)
12/2019
1Cysts
12/2019
1Headache (Headaches)
12/2019
1Diaphragmatic Hernia
12/2019
1Premature Obstetric Labor (Premature Labor)
12/2019
1Lung Diseases (Lung Disease)
12/2019
1Migraine Disorders (Migraine)
12/2019
1Mitral Valve Prolapse
12/2019
1Muscular Diseases (Myopathy)
12/2019
1Pain (Aches)
12/2019
1Prolapse
12/2019
1Schizophrenia (Dementia Praecox)
12/2019
1Tricuspid Valve Prolapse
12/2019
1Urinary Incontinence
12/2019
1von Willebrand Diseases (von Willebrand's Disease)
12/2019
1Cognitive Dysfunction
12/2019
1Cerebrospinal Fluid Leak
12/2019
1Aortic Coarctation
05/2019
1Ventricular Heart Septal Defects (Ventricular Septal Defect)
05/2019
1Patent Ductus Arteriosus
10/2018
1Pulmonary Arterial Hypertension
10/2018
1Substance-Related Disorders (Drug Abuse)
12/2017
1Ventricular Dysfunction
12/2017
1Acute Coronary Syndrome
12/2017
1Spontaneous Remission
12/2017
1Hypertelorism
12/2016
1Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
04/2014
1Familial Thoracic 1 Aortic Aneurysm
05/2013
1Joint Instability (Joint Laxity)
10/2012
1Iron Deficiencies
11/2011
1Pulmonary Hypertension
10/2011

Drug/Important Bio-Agent (IBA)

7Fibrillin-1IBA
01/2021 - 08/2009
5Losartan (Cozaar)FDA LinkGeneric
01/2018 - 05/2013
41,3,4,6- tetra- O- acetyl- 2- azido- 2- deoxyglucopyranose (TAAD)IBA
01/2021 - 05/2013
4Transforming Growth Factor-beta Type I ReceptorIBA
11/2019 - 01/2012
4Atenolol (Tenormin)FDA LinkGeneric
01/2018 - 05/2013
3Transforming Growth Factor-beta Type II ReceptorIBA
11/2019 - 01/2012
3Transforming Growth Factor beta (TGF-beta)IBA
08/2009 - 03/2005
2Transforming Growth Factors (Transforming Growth Factor)IBA
06/2022 - 01/2014
2Nitric Oxide (Nitrogen Monoxide)FDA Link
11/2021 - 02/2017
2Proteins (Proteins, Gene)FDA Link
01/2021 - 01/2019
2Extracellular Matrix ProteinsIBA
01/2021 - 09/2020
2Arginine (L-Arginine)FDA Link
10/2018 - 04/2007
2Angiotensin Receptor AntagonistsIBA
05/2015 - 04/2014
2liposomal doxorubicin (Doxil)FDA Link
12/2008 - 08/2008
1Biomarkers (Surrogate Marker)IBA
11/2021
1Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA
11/2021
1Soluble Guanylyl CyclaseIBA
11/2021
1Pharmaceutical PreparationsIBA
01/2021
1FibrillinsIBA
10/2020
1Growth Hormone (Somatotropin)IBA
08/2020
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2020
1Angiotensin Receptors (Angiotensin II Receptor)IBA
12/2019
1AnticoagulantsIBA
12/2019
1ThrombinFDA Link
12/2019
1AminopropionitrileIBA
01/2018
1Metalloproteases (Metalloproteinases)IBA
02/2017
14-S-(propionic acid)sulfidocyclophosphamide (PASP)IBA
12/2014
1Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
04/2014
1Hydralazine (Apresoline)FDA LinkGeneric
04/2014
1Collagen Type V (Type V Collagen)IBA
10/2012
1IronIBA
11/2011
1CreatinineIBA
10/2011

Therapy/Procedure

8Therapeutics
01/2021 - 08/2008
2Transplantation
10/2015 - 09/2013
1Transition to Adult Care
11/2021
1Endovascular Aneurysm Repair
01/2021
1Continuity of Patient Care
02/2020
1Transitional Care
02/2020
1Fontan Procedure (Fontan Operation)
05/2019
1Synchrotrons
01/2018
1Conservative Treatment
12/2017
1Heart Transplantation (Grafting, Heart)
10/2015